What is the difference between the “Nationwide Weekly Molecular Detection of Respiratory Pathogens” and the “Weekly Trend of Positive Specimens for Designated Respiratory Pathogens Reported via the Laboratory Automated Reporting System (LARS)” trend charts?

Both systems are laboratory-based surveillance platforms aimed at monitoring the activity of important respiratory pathogens. However, they differ in specimen sources, testing methods, reporting timeliness, etc. These systems complement each other as part of a multi-source surveillance approach to enhance sensitivity. Interpretation of trends should be made in conjunction with various surveillance indicators for a comprehensive assessment of the epidemic situation.

NHIA historical data has been modified starting from March 13, 2025

Due to practical needs, the age stratification method of the NHIA data has been adjusted. Starting from March 13, 2025, the NHIA data will be reprocessed. As a result, historical health insurance consultation data has been modified since 2016.

Description of the “Nationwide Weekly Respiratory Pathogens/Influenza Virus/Enterovirus Detection”

The source of data on pathogen detection is from Contracted Virology Laboratories surveillance. Before 2024 (inclusive), the laboratories adopted the testing method of virus isolation, culture, and identification. Since 2025, the testing method has been adjusted to molecular detection; therefore, the results from these two methods will be presented separately.

What SARS-CoV-2 variants are currently being monitored?

1. The trend chart includes variants classified by the World Health Organization as current or former variants of interest (VOI), variants under monitoring (VUM), key domestic variants, and others (e.g. recombinant variants).
2. In the future, variant information may be adjusted due to factors such as the inclusion of new variants by the WHO, reclassification/renaming of variants, or the need for enhanced monitoring.

Description of the “Real-time Outbreak and Disease Surveillance System (RODS)”

The Real-time Outbreak and Disease Surveillance System (RODS) collects and analyzes data from more than 170 designated hospitals nationwide. Through this system, diagnostic codes and other related information from emergency departments are automatically and continuously transmitted in real time to the Taiwan Centers for Disease Control (TCDC).
The system enables early and rapid detection of abnormal patterns or signals in various diseases or syndromes. It was established to identify potential infectious disease outbreaks in the community at an early stage and to track and forecast epidemic trends.
In 2007, the system monitored influenza-like illness (ILI), enterovirus infection, and diarrhea. Since 2008, acute hemorrhagic conjunctivitis (AHC) has also been included as a monitored disease.
Data Analysis Method: Over 170 designated hospitals transmit emergency department data in real time via the Internet every day. The main data fields include basic patient information, hospital code, admission time, chief complaint, and ICD-9-CM/ICD-10-CM diagnostic codes.
The TCDC compiles and analyzes RODS data weekly to assess epidemic trends and produces statistical charts, which are published on the official TCDC website.

How to cite this website?

Example of citation: "Taiwan National Infectious Disease Statistics System [Internet]. Taipei (Taiwan): Taiwan Centers for Disease Control; c2014 [updated 2014 Apr 13; cited 2014 Apr 15]. Available from: http://nidss.cdc.gov.tw/en/."

How are the weekly alert and epidemic thresholds for each notifiable infectious disease calculated?

Alert threshold: The mean number of confirmed cases for each corresponding week over the past five years.
Epidemic threshold: The mean number of confirmed cases for each corresponding week over the past five years plus two times the standard deviation (mean + 2 × SD).

How is the week numbering defined in this system?

Week calculation: Each week begins on Sunday and ends on Saturday. Week 1 of each year is defined as the week that includes January 4.
For a complete correspondence between weeks and calendar dates, please refer to the “Week–Year Reference Table.

How often are the statistical data updated?

The Taiwan National Infectious Disease Statistics System is derived from the Taiwan CDC Data Warehouse System.
Statistical data on notifiable infectious diseases are updated daily at 8:30 a.m. Data from LARS, RODS, and National Health Insurance secondary statistics are updated early every Monday and Tuesday morning to ensure the completeness of weekly data. The datasets on “Nationwide Weekly Molecular Detection of Respiratory Pathogens / Influenza Viruses / Enteroviruses” are updated early every Saturday and Sunday morning.

When opening downloaded data files in Excel, some fields are automatically displayed in date format

Some downloaded datasets may contain fields that Excel automatically converts to date formats.
To prevent this issue, you can open the file using a plain text editor (such as Notepad, Notepad++, or WordPad), or by processing it through a program interface.
If you need to work with the data in Excel, please follow the steps below after downloading the file:
On the toolbar, select“Data”→“Get External Data”→“From Text File.”Choose comma-separated (CSV) as the delimiter.
When specifying column formats, set fields such as “Age group” to Text before importing.
This will prevent Excel from automatically converting numeric or text values into dates.

How are the weekly numbers of pneumonia and influenza deaths calculated in the “Weekly Pneumonia and Influenza Mortality Surveillance” chart on the Influenza webpage?

After the outbreak of the novel influenza A (H1N1) in mid-April 2009, the Taiwan CDC collaborated with the Department of Statistics, Ministry of Health and Welfare, to establish a mortality surveillance system for pneumonia and influenza.
Through the Death Reporting Network System, daily death notifications are electronically transmitted to Taiwan CDC. Causes of death identified by searching for the keywords pneumonia, common cold, or influenza, and analyzed in conjunction with cause-of-death classification rules to generate weekly statistics on pneumonia and influenza mortality trends.
For details on the data analysis method, please refer to:
http://www.cdc.gov.tw/downloadfile.aspx?fid=03531D876CD55C48

How is the nationwide epidemic threshold for enterovirus outpatient and emergency visits calculated?

Explanation of the epidemic threshold:

1. Calculation Method: The mean and standard deviation (SD) are calculated based on the number of outpatient and emergency visits for enterovirus infection during non-epidemic weeks over the past three years.
The epidemic threshold is defined as mean+1.64×SD (the upper limit of the 90% confidence interval).

Note: Non-epidemic weeks are defined as weeks in which the number of enterovirus-positive specimens in the community accounts for less than 1.92% of the total annual number of positive specimens for two consecutive weeks.

(Assuming enterovirus-positive specimens are evenly distributed across 52 weeks in a year, the expected weekly percentage would be 1/52=1.92%.)

2. Interpretation: When the total number of outpatient and emergency visits for enterovirus infection exceeds the epidemic threshold, it indicates that the enterovirus infection has entered the epidemic phase.

What are the ICD codes for disease categories used in the Emergency Department Infectious Disease Surveillance Statistics (RODS, Real-time Outbreak and Disease Surveillance System)?

‧Enterovirus infection: 008.67, 047, 047.0, 047.1, 048, 074, 074.0, 074.1, 074.2, 074.20, 074.21, 074.22, 074.23, 074.3, 074.8, 079.1, 079.2
‧Herpangina: 074.0
‧Hand, foot and mouth disease: 074.3
‧Acute hemorrhagic conjunctivitis (AHC): 077, 077.0, 077.1, 077.2, 077.3, 077.4, 077.8, 077.9, 370.4, 370.40, 372, 372.0, 372.00, 372.71, 372.72
‧Influenza-like illness (RODS ILI): 003.22, 010, 010.0, 010.00, 010.01, 010.02, 010.03, 010.04, 010.05, 010.06, 010.1, 010.10, 010.11, 010.12, 010.13, 010.14, 010.15, 010.16, 010.8, 010.80, 010.81, 010.82, 010.83, 010.84, 010.85, 010.86, 010.9, 010.90, 010.91, 010.92, 010.93, 010.94, 010.95, 010.96, 011, 011.0, 011.00, 011.01, 011.02, 011.03, 011.04, 011.05, 011.06, 011.1, 011.10, 011.11, 011.12, 011.13, 011.14, 011.15, 011.16, 011.2, 011.20, 011.21, 011.22, 011.23, 011.24, 011.25, 011.26, 011.3, 011.30, 011.31, 011.32, 011.33, 011.34, 011.35, 011.36, 011.4, 011.40, 011.41, 011.42, 011.43, 011.44, 011.45, 011.46, 011.5, 011.50, 011.51, 011.52, 011.53, 011.54, 011.55, 011.56, 011.6, 011.60, 011.61, 011.62, 011.63, 011.64, 011.65, 011.66, 011.7, 011.70, 011.71, 011.72, 011.73, 011.74, 011.75, 011.76, 011.8, 011.80, 011.81, 011.82, 011.83, 011.84, 011.85, 011.86, 011.9, 011.90, 011.91, 011.92, 011.93, 011.94, 011.95, 011.96, 020, 020.3, 020.4, 020.5, 020.9, 021.2, 022, 022.1, 024, 025, 032, 032.0, 032.1, 032.2, 032.3, 032.89, 033, 033.0, 033.1, 033.8, 033.9, 034, 034.0, 052.1, 055.1, 073, 073.0, 074.1, 079, 079.8, 079.81, 079.88, 079.89, 079.9, 079.98, 079.99, 083.0, 112.4, 114.0, 114.9, 115, 115.0, 115.00, 115.05, 115.15, 115.9, 115.90, 115.95, 130.4, 136.3, 460, 462, 463, 464, 464.0, 464.1, 464.10, 464.11, 464.2, 464.20, 464.21, 464.3, 464.30, 464.31, 464.4, 465, 465.0, 465.8, 465.9, 466, 466.0, 466.1, 466.11, 466.19, 480, 480.0, 480.1, 480.2, 480.8, 480.9, 481, 482, 482.0, 482.1, 482.2, 482.3, 482.30, 482.31, 482.32, 482.39, 482.4, 482.40, 482.41, 482.49, 482.8, 482.81, 482.82, 482.83, 482.84, 482.89, 482.9, 483, 483.0, 483.1, 483.8, 484, 484.1, 484.3, 484.5, 484.6, 484.7, 484.8, 485, 486, 487, 487.0, 487.1, 490, 491, 491.0, 491.1, 491.20, 491.21, 491.8, 491.9, 507, 507.0, 507.1, 507.8, 511, 511.0, 511.1, 511.8, 511.9, 513, 513.0, 513.1, 518, 518.0, 518.4, 518.8, 518.81, 518.82, 518.84, 518.89, 519.2, 784.1, 786.0, 786.00, 786.05, 786.06, 786.07, 786.09, 786.1, 786.2, 786.52, 795.31, V01.81
see also Chapman et al, Generating a Reliable Reference Standard Set for Syndromic Case Classification, J Am Med Inform Assoc. 2005 Nov-Dec;12(6):618-29.
https://pmc.ncbi.nlm.nih.gov/articles/PMC1294033/pdf/618.pdf

‧Acute diarrhea: 001, 001.0, 001.1, 001.9, 002, 002.0, 002.1, 002.2, 002.3, 002.9, 003, 003.0, 003.1, 003.2, 003.20, 003.21, 003.22, 003.23, 003.24, 003.29, 003.8, 003.9, 004, 004.0, 004.1, 004.2, 004.3, 004.8, 004.9, 005.0, 005.1, 005.2, 005.3, 005.4, 005.8, 005.81, 005.89, 005.9, 006, 006.0, 006.2, 006.9, 007, 007.0, 007.1, 007.2, 007.3, 007.4, 007.5, 007.8, 007.9, 008, 008.0, 008.00, 008.01, 008.02, 008.03, 008.04, 008.09, 008.1, 008.2, 008.3, 008.4, 008.41, 008.42, 008.43, 008.44, 008.45, 008.46, 008.47, 008.49, 008.5, 008.6, 008.61, 008.62, 008.63, 008.64, 008.65, 008.66, 008.67, 008.69, 008.8, 009, 009.0, 009.1, 009.2, 009.3, 558, 558.9, 787.91, 988
‧COVID-19 infection: U07.1

ICD Code Reference Table by Disease Category for National Health Insurance Secondary Statistical Data

Disease ICD-9 ICD-10
Enterovirus infection Hand, foot and mouth disease 074.3 B08.4
Herpangina 074.0 B08.5
Influenza-like illness(ILI) Other pneumonia 480 J12-
481 J13-
482 J14-
J15-
483 J16-
484 B25-
A37-
A22-
B44-
J17-
485  
486 J18-
Influenza and pneumonia caused by influenza 487 J09-
J10-
J11-
Acute upper respiratory infection 465.9 J06.9
Diarrhea 009.0 A08-
558.9 K52-
787 R19.7
Scarlet fever 034.1 A38-
Varicella 052- B01-
COVID-19 infection   U07.1
Acute hemorrhagic conjunctivitis (AHC) Viral conjunctivitis   B30-
Conjunctivitis   H10-
Conjunctival hemorrhage   H11.3-